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Guide Glossary
 Medical Oncology

Megestrol acetate (Megace®)

How does this drug work?

Megace® is a progesterone-like drug which prevents the activity of hormones that can cause breast cancer to grow.


Common side effects

  • Swelling of the hands and feet

  • Weight gain

  • Increased appetite

  • Vaginal bleeding or missed period

Less common side effects with your type of chemotherapy:

  • Skin rash

  • Blood clots and inflammation of a vein (phlebitis)

  • Mental depression, mood changes

Usual Dosing

The usual dose is 40-mg orally four times a day and may be taken with or without food.

As with any drug, other side effects that were not mentioned may occur


General concerns

  • Oral contraceptives (the "pill") are not recommended for women with breast cancer. Ask your doctor about a birth control method for you.

  • If you become pregnant, tell your doctor or nurse immediately

  • If you are planning to become pregnant, consult with your doctor first

  • Report to your doctor any side effect you may experience

  • Report any symptoms which are unusual for you


During the day, you may reach a doctor or nurse by calling the Breast Care Center Oncology/Chemotherapy number (see phone list).

After hours and on weekends, please be sure to use the specified Oncology/Chemotherapy, as this is the ONLY number to connect you to the appropriate physician on call.