Letrozole (Femara®)

How does this drug work?

Letrozole is a hormonal drug that prevents the growth of breast cancer by inhibiting the enzyme aromatase, which is involved in the production of estrogen. Letrozole significantly lowers the amount of estrogen in post-menopausal women by inhibiting inhibiting the conversion of androgens (made in the adrenal glands) to estrogen. It is taken orally in a 25-mg dose daily after a meal. It is currently indicated for postmenopausal women with advanced breast cancer. It should not be take by premenopausal women after progression or prior treatment with tamoxifen.

General Side Effects Femara® (letrozole tablets) was generally well tolerated in two controlled clinical trials.
Only about 3% of patients discontinued Femara®.

Common side effects

• Muscle aches and bone pain (Includes back pain, arm pain, leg pain) ­ probable tumor flare -(21%)

• Hot flashes (6%)

• Headache (9%)

• Nausea or vomiting (9%)

• Fatigue (8%)

• Fluid retention (5%)

• Increased appetite (3%)

• Constipation or diarrhea (6%)

• Weakness (4%)

• Shortness of breath or coughing (6-7%)

Less common side effects with your type of chemotherapy:

• Weight gain

• Rash

• Increased perspiration

• Dizziness

General concerns

• Report vomiting or nausea that is not relieved with anti-nausea medication.

• Immediately report any fevers of 101ƒ or higher, with or without chills

• Report nose bleeds, gum bleeding, or any unusual bruising

• Ask your doctor about a birth control method for you

• Report any symptoms that are unusual for you

• Report any swelling which is uncomfortable

• Report any shortness of breath